Stimulant medication use and response to growth hormone therapy: an NCGS database analysis.

Full Abstract

BACKGROUND/AIMS: Determine (1) frequency of attention-deficit hyperactivity disorder (ADHD) treatment and (2) growth responses in growth hormone (GH)-treated children who are receiving ADHD medication versus GH alone. METHODS: Prepubertal children with idiopathic short stature (ISS) or GH deficiency (IGHD) enrolled in Genentech's National Cooperative Growth Study. ADHD treatment was determined by documentation of psycho-stimulant medication use at enrollment. RESULTS: ADHD medication use increased from 0.8% (7/850) in 1985 to 5.8% (752/12,113) in 2005. First-year GH treatment response for ADHD + IGHD versus IGHD: 8.5 +/- 2.0 vs. 9.4 +/- 2.6 cm/year, but when adjusted for age, sex, and enrollment body mass index, the difference is clinically insignificant (-0.4 cm/year). First-year growth was similar in all ISS: 8.1 +/- 1.9 versus 8.6 +/- 2.1 cm/year (ADHD + ISS vs. ISS, an adjusted -0.2-cm/year difference). CONCLUSION: Increasing numbers of GH-treated children are taking ADHD medications and their growth responses during the first year of GH therapy are similar to those not taking ADHD medications. Copyright 2009 S. Karger AG, Basel.

Author information

Author/s: Frindik, J Paul (JP); Morales, Alba (A); Fowlkes, John (J); Kemp, Stephen (S); Thrailkill, Kathryn (K); Lippe, Barbara (B); Dana, Ken (K);

Affiliation: University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. frindikpaul(-atsign-)uams.edu

Journal and publication information

Publication Type: Clinical Trial, Phase IV; Journal Article; Multicenter Study

Journal: Hormone research (Horm Res), published in Switzerland. (Language: eng)

Reference: 2009-; vol 72 (issue 3) : pp 160-6

Dates: Created 2009/09/04; Completed 2009/11/06;

PMID: 19729947, status: MEDLINE (last retrieval date: 11/6/2009, IMS Date: )

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