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| Research article summary (published 30 Aug 2009): |
A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.
Full Abstract
OBJECTIVE: To characterize the serum metabolome of a primate model of in utero high-fat exposure. STUDY DESIGN: Serum from maternal and fetal (e130) macaque monkeys exposed to either a high-fat or control diet were analyzed by gas chromatography-mass spectrometry. Multivariate data analysis was performed to reduce the generated data set. Candidate metabolites were further analyzed for significance by using the analysis of variance and comparative t tests. RESULTS: Approximately 1300 chromatographic features were detected. Through multivariate data analysis this number was reduced to 60 possible metabolites. With the use of comparative t tests, 22 metabolites had statistical significance (P < .05) over the entire study. By virtue of maternal high-fat diet alone, fetal phenotypic differences are accompanied by altered metabolite concentrations of 7 metabolites (P < .05). CONCLUSION: In utero high-fat diet exposure is associated with an altered fetal epigenome and parlays a characteristic modification in the fetal metabolite profile.
Author information
Author/s: Cox, James (J); Williams, Sarah (S); Grove, Kevin (K); Lane, Robert H (RH); Aagaard-Tillery, Kjersti M (KM);
Affiliation: Metabolomics Core Research Facility, University of Utah Health Sciences, Salt Lake City, UT, USA.
Grants: 1R01DK079194 (Agency:NIDDK NIH HHS) ; 1R01DK080558 (Agency:NIDDK NIH HHS) ; DK60685-0351 (Agency:NIDDK NIH HHS) ; DP21DP2OD001500-01 (Agency:NCCDPHP CDC HHS) ; RR00163 (Agency:NCRR NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol), published in United States. (Language: eng)
Reference: 2009-Sep; vol 201 (issue 3) : pp 281.e1-9
Dates: Created 2009/09/07; Completed 2009/10/08;
PMID: 19733280, status: MEDLINE (last retrieved date: 10/8/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Dietary Fats (0)Related articles
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