Oral fluid, a substitute for serum to monitor measles IgG antibody?

Full Abstract

We have analyzed the suitability and potential of Oral Fluid (OF) to substitute serum in estimating measles IgG antibodies, during community surveys, by comparing the Optical Density (OD) of measles IgG antibodies in OF and serum of 100 apparently asymptomatic children. IgG antibody status was determined using commercially available - Measles IgG Capture ELISA. Sensitivity 89.5%, specificity 90.6% Concordance of 89%, coefficient of correlation r is equal to 0.97 (Karl Pearson's) and rho is equal to 0.86 (Spearman's), was found between OD value of OF and serum. The study emphasizes the potential of OF to surrogate serum in estimating Measles IgG antibody among children. The OF collection is advantageous over blood as it is painless. It is suitable for non-technical staff, easy to transport and less bio-hazardous.

Author information

Author/s: Goyal, A (A); Shaikh, N J (NJ); Kinikar, A A (AA); Wairagkar, N S (NS);

Affiliation: Department of Paediatrics, B J Medical College and Sassoon General Hospitals, Pune, India. goyalaa1986(-atsign-)yahoo.com

Journal and publication information

Publication Type: Comparative Study; Evaluation Studies; Journal Article

Journal: Indian journal of medical microbiology (Indian J Med Microbiol), published in India. (Language: eng)

Reference: -2009 Oct-Dec; vol 27 (issue 4) : pp 351-3

Dates: Created 2009/09/08; Completed 2009/11/02;

PMID: 19736406, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

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