Research article summary (published 30 Jul 2009):

A washout period needed before switching from a neuroleptic to an amphetamine.

Full Abstract

(1) Abrupt replacement of risperidone with methylphenidate can lead to severe agitation in children; (2) Abruptly switching from one pharmacological class to another can lead to complications.

Author information

Journal and publication information

Publication Type: Journal Article

Journal: Prescrire international (Prescrire Int), published in France. (Language: eng)

Reference: 2009-Aug; vol 18 (issue 102) : pp 165

Dates: Created 2009/09/10; Completed 2009/09/28;

PMID: 19743579, status: MEDLINE (last retrieval date: 9/28/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Amphetamines - administration & dosage; adverse effects; therapeutic use Antipsychotic Agents - administration & dosage; adverse effects; therapeutic use Attention Deficit Disorder with Hyperactivity - drug therapy Child

Drug Interactions Humans Methylphenidate - administration & dosage; adverse effects; therapeutic use Psychomotor Agitation Risperidone - administration & dosage; adverse effects; therapeutic use

Associated Chemicals: Amphetamines (0) ; Antipsychotic Agents (0) ; Risperidone (106266-06-2) ; Methylphenidate (113-45-1)

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