A 76-year-old man with cognitive and neurological symptoms.

Full Abstract

A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.

Author information

Author/s: Brunnström, Hans (H); Dictor, Michael (M); Nilsson, Christer (C); Gülich, Dag (D); Englund, Elisabet (E);

Journal and publication information

Publication Type: Case Reports; Letter

Journal: Brain pathology (Zurich, Switzerland) (Brain Pathol), published in Switzerland. (Language: eng)

Reference: 2009-Oct; vol 19 (issue 4) : pp 731-4

Dates: Created 2009/09/11; Completed 2009/11/04;

PMID: 19744045, status: MEDLINE (last retrieval date: 11/4/2009, IMS Date: )

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