Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan.

Full Abstract

We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6')-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

Author information

Author/s: Chang, Chung-Yu (CY); Fang, Yu-Ti (YT); Tsai, Shih-Meng (SM); Chang, Lin-Li (LL); Yu, Wen-Liang (WL);

Affiliation: Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis), published in United States. (Language: eng)

Reference: 2009-Oct; vol 65 (issue 2) : pp 214-6

Dates: Created 2009/09/14; Completed 2009/11/06;

PMID: 19748438, status: MEDLINE (last retrieval date: 11/6/2009, IMS Date: )

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