Research article summary (published 11 Sep 2009):

Selective suppression of hippocampal ripples impairs spatial memory.

Full Abstract

Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

Author information

Author/s: Girardeau, Gabrielle (G); Benchenane, Karim (K); Wiener, Sidney I (SI); Buzsáki, György (G); Zugaro, Michaël B (MB);

Affiliation: Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France.

Grants: NS34994 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Nature neuroscience (Nat Neurosci), published in United States. (Language: eng)

Reference: 2009-Oct; vol 12 (issue 10) : pp 1222-3

Dates: Created 2009/09/28; Completed 2009/10/13;

PMID: 19749750, status: MEDLINE (last retrieval date: 10/13/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - physiology Analysis of Variance Animals Behavior, Animal Biophysics Electric Stimulation - methods Electroencephalography - methods Evoked Potentials - physiology Hippocampus - cytology; physiology Male

Maze Learning - physiology Memory Disorders - physiopathology Nerve Net - physiology Neural Inhibition - physiology Neurons - physiology Online Systems Rats Rats, Long-Evans Space Perception - physiology Spectrum Analysis - methods

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