Research article summary (published 8 Sep 2009):

The eyes have it: hippocampal activity predicts expression of memory in eye movements.

Full Abstract

Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex and functional connectivity between the hippocampus and prefrontal cortex were greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails and that recruitment of a broader cortical network may be required to support explicit associative recognition.

Author information

Author/s: Hannula, Deborah E (DE); Ranganath, Charan (C);

Affiliation: Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95618, USA. dehannula(-atsign-)ucdavis.edu

Grants: F32MH075513 (Agency:NIMH NIH HHS) ; MH68721 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2009-Sep; vol 63 (issue 5) : pp 592-9

Dates: Created 2009/09/16; Completed 2009/10/13;

PMID: 19755103, status: MEDLINE (last retrieval date: 10/13/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Neuron. 2009 Sep 10;63(5):561-3. (PMID: 19755098)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance Association Learning - physiology Cues Eye Movement Measurements Eye Movements - physiology Face Female Hippocampus - physiology Humans Magnetic Resonance Imaging

Male Memory - physiology Neural Pathways Neuropsychological Tests Photic Stimulation Prefrontal Cortex - physiology Reaction Time Recognition (Psychology) - physiology Temporal Lobe - physiology Time Factors

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