Research article summary (published 10 Sep 2009):

Comparison of stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neurinomas according to 3-D tumor volume shrinkage and quality of life.

Full Abstract

BACKGROUND AND PURPOSE: Stereotactic radiosurgery (SRS) and also fractionated stereotactic radiotherapy (SRT) offer high local control (LC) rates (> 90%). This study aimed to evaluate three-dimensional (3-D) tumor volume (TV) shrinkage and to assess quality of life (QoL) after SRS/SRT. PATIENTS AND METHODS: From 1999 to 2005, 35/74 patients were treated with SRS, and 39/74 with SRT. Median age was 60 years. Treatment was delivered by a linear accelerator. Median single dose was 13 Gy (SRS) or 54 Gy (SRT). Patients were followed up > or = 12 months after SRS/SRT. LC and toxicity were evaluated by clinical examinations and magnetic resonance imaging. 3-D TV shrinkage was evaluated with the planning system. QoL was assessed using the questionnaire Short Form-36. RESULTS: Median follow-up was 50/36 months (SRS/SRT). Actuarial 5-year freedom from progression/overall survival was 88.1%/100% (SRS), and 87.5%/87.2% (SRT). TV shrinkage was 15.1%/40.7% (SRS/SRT; p = 0.01). Single dose (< 13 Gy) was the only determinant factor for TV shrinkage after SRS (p = 0.001). Age, gender, initial TV, and previous operations did not affect TV shrinkage. Acute or late toxicity (> or = grade 3) was never seen. Concerning QoL, no significant differences were observed after SRS/SRT. Previous operations and gender did not affect QoL (p > 0.05). Compared with the German normal population, patients had worse values for all domains except for mental health. CONCLUSION: TV shrinkage was significantly higher after SRT than after SRS. Main symptoms were not affected by SRS/SRT. Retrospectively, QoL was neither affected by SRS nor by SRT.

Author information

Author/s: Henzel, Martin (M); Hamm, Klaus (K); Sitter, Helmut (H); Gross, Markus W (MW); Surber, Gunnar (G); Kleinert, Gabriele (G); Engenhart-Cabillic, Rita (R);

Affiliation: Department of Radiation Oncology, Philipps University Marburg, Baldingerstrasse, Marburg, Germany. henzel(-atsign-)med.uni-marburg.de

Journal and publication information

Publication Type: Journal Article

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] (Strahlenther Onkol), published in Germany. (Language: eng)

Reference: 2009-Sep; vol 185 (issue 9) : pp 567-73

Dates: Created 2009/09/16; Completed 2009/10/23;

PMID: 19756422, status: MEDLINE (last retrieval date: 10/23/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Female Follow-Up Studies Humans Male Middle Aged

Neuroma, Acoustic - pathology; physiopathology; psychology; radiotherapy Patient Care Planning Quality of Life Radiosurgery - methods Time Factors

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