Risk factors for respiratory failure associated with respiratory syncytial virus infection in adults.

Full Abstract

Risk factors associated with respiratory failure during respiratory syncytial virus (RSV) infection have not been assessed in adults. We identified RSV by quantitative reverse transcription polymerase chain reaction in 58 adults during the 2007-2008 winter. Clinical variables and respiratory secretion viral loads were compared in 26 outpatients and 32 inpatients. Cardiopulmonary diseases were more common among inpatients than outpatients (91% vs 31%, P = .0001), whereas mean RSV load was similar. Nasal viral load was higher in ventilated vs nonventilated hospitalized patients (log(10) 3.7 +/- 1.7 plaque-forming units (PFUs)/mL vs 2.4 +/- 1.1 PFUs/mL, P = .02), and high viral load was independently associated with respiratory failure.

Author information

Author/s: Duncan, Coley B (CB); Walsh, Edward E (EE); Peterson, Derick R (DR); Lee, F Eun-Hyung (FE); Falsey, Ann R (AR);

Affiliation: Department of Medicine, Rochester General Hospital, Rochester, New York 14621-3001, USA.

Grants: 2U01 AI045969-05A1 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: The Journal of infectious diseases (J Infect Dis), published in United States. (Language: eng)

Reference: 2009-Oct; vol 200 (issue 8) : pp 1242-6

Dates: Created 2009/09/23; Completed 2009/10/29;

PMID: 19758094, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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