Research article summary (published 30 Aug 2009):

Autoimmune thyroid disease and autoimmune rheumatic disorders: a two-sided analysis.

Full Abstract

Chronic autoimmune thyroiditis (ATD) frequently overlaps with autoimmune rheumatic diseases. The aim of this study was to evaluate the prevalence of various non-organ-specific autoantibodies in patients with ATD, as well as the presence of ATD in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SUBJECTS AND METHODS: Group 1 comprised 80 patients with ATD, and group 2 contained 80 patients with SLE or RA. A control group consisted of 34 healthy subjects. Group 1 was examined for the presence of non-organ-specific autoantibodies. Serum fT3, fT4, TSH, and antibodies against thyroglobulin, thyroperoxidase, as well as ultrasound of thyroid gland, were determined in group 2. RESULTS: Patients with ATD had a significantly higher prevalence of antinuclear antibodies (ANA) than control subjects (45% vs. 14.7%, P < 0.001). There were no significant differences in the prevalence of other antibodies between the groups. ANA-positive patients were younger than ANA-negative ones and had significantly higher anti-TG values (P < 0.05). The prevalence of ATD in group 2 was significantly higher than in the control subjects (24% vs. 8%, P < 0.05). No significant differences in the prevalence of ATD were detected between SLE and RA. CONCLUSION: The authors conclude that ANA is the most frequent non-organ-specific antibody associated with ATD, while the other antibodies occur rarely. The prevalence of ATD in SLE and RA patients was 24%. These results indicate that it is clinically important to screen patients with SLE and RA for the coexistence of thyroid autoimmune disease.

Author information

Author/s: Lazúrová, Ivica (I); Benhatchi, Karim (K); Rovenský, Jozef (J); Kozáková, Darina (D); Wagnerová, Hedviga (H); Tajtáková, Mária (M); Shoenfeld, Yehuda (Y); Macejova, Z (Z);

Affiliation: 1st Department of Internal Medicine, Medical Faculty, Pavol Jozef Sáfarik University, Kosice, Slovakia.

Journal and publication information

Publication Type: Journal Article

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 1173 (issue ) : pp 211-6

Dates: Created 2009/09/17; Completed 2009/10/29;

PMID: 19758153, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Aged, 80 and over Antibodies, Antinuclear - blood Arthritis, Rheumatoid - diagnosis Autoantibodies - blood Cell Line, Tumor Diagnosis, Differential Enzyme-Linked Immunosorbent Assay - methods Female Fluorescent Antibody Technique, Indirect - methods Humans

Humans Iodide Peroxidase - immunology Lupus Erythematosus, Systemic - diagnosis Male Middle Aged Thyroglobulin - immunology Thyroid Gland - immunology; pathology Thyroiditis, Autoimmune - diagnosis Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood Young Adult

Associated Chemicals: Antibodies, Antinuclear (0) ; Autoantibodies (0) ; Triiodothyronine (6893-02-3) ; Thyroxine (7488-70-2) ; Thyrotropin (9002-71-5) ; Thyroglobulin (9010-34-8) ; Iodide Peroxidase (EC 1.11.1.8)

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