Autoimmunity triggers in the NOD mouse: a role for natural auto-antibody reactivities in type 1 diabetes.

Full Abstract

The nonobese diabetic mouse (NOD) is widely used as a model to study human type 1 diabetes (T1D). In the NOD mouse T1D is a T cell-mediated autoimmune disease of complex etiology in which B cells play an essential role. One of the major unresolved issues in T1D is the genetic and/or environmental factors that trigger the autoimmune reaction. In the NOD mouse, as in humans, auto-antibodies to pancreatic islets are present at early ages and are highly correlated to diabetes progression, but their etiological role has long been disputed. NOD auto-antibodies have the characteristics of a natural repertoire, and B1 cells, the main natural antibody producers, exhibit functional differences in this strain that could have consequences for disease determination. Using a genetic approach, we propose to test if the NOD natural auto-antibody repertoire includes innate reactivities that participate in diabetes pathogenesis by promoting insulitis initiation.

Author information

Author/s: Côrte-Real, Joana (J); Duarte, Nádia (N); Tavares, Luís (L); Penha-Gonçalves, Carlos (C);

Affiliation: Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 1173 (issue ) : pp 442-8

Dates: Created 2009/09/17; Completed 2009/10/29;

PMID: 19758184, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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