Preventing viral-induced type 1 diabetes.

Full Abstract

The development of type 1 diabetes is, in part, dictated by the failure of regulatory T cells to maintain peripheral tolerance. As such, therapies aimed at correcting the declining function of regulatory T cells have been the subject of intense investigation. In this review, we discuss the potential of regulatory T cells to suppress autoreactive responses and prevent type 1 diabetes induced by viral infection while maintaining protective antiviral immunity.

Author information

Author/s: Richer, Martin Joseph (MJ); Horwitz, Marc Steven (MS);

Affiliation: Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 1173 (issue ) : pp 487-92

Dates: Created 2009/09/17; Completed 2009/10/29;

PMID: 19758190, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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