Sugar-free antibodies--the bacterial solution to autoimmunity?

Full Abstract

The enzyme EndoS from Streptococcus pyogenes is an immunomodulatory molecule hydrolyzing the conserved glycans in the effector part of immunoglobulin G (IgG). EndoS is remarkably specific for IgG, and hydrolysis has profound effects on IgG effector functions. EndoS pretreatment of IgG, or direct administration to animals with experimental antibody-mediated autoimmune diseases, inhibits development of disease or cures animals from established disease. The properties of EndoS make it a unique experimental tool and an attractive alternative to current therapies of conditions involving pathogenic antibodies. This review describes the discovery of EndoS, the effects of EndoS on IgG effector functions in vitro and in vivo, the biotechnological potential of EndoS, and the outcomes of EndoS treatment in animal models of autoimmunity.

Author information

Author/s: Allhorn, Maria (M); Collin, Mattias (M);

Affiliation: Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 1173 (issue ) : pp 664-9

Dates: Created 2009/09/17; Completed 2009/10/29;

PMID: 19758213, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Autoimmune Diseases - immunology; prevention & control
Autoimmunity - drug effects; immunology
Bacterial Proteins - administration & dosage; metabolism
Disease Models, Animal
Glycoside Hydrolases - administration & dosage; metabolism

Glycoside Hydrolases - administration & dosage; metabolism
Humans
Immunoglobulin G - chemistry; metabolism
Polysaccharides - metabolism
Protein Conformation
Substrate Specificity

Associated Chemicals: Bacterial Proteins (0) ; Immunoglobulin G (0) ; Polysaccharides (0) ; Glycoside Hydrolases (EC 3.2.1.-) ; NDOS protein, Streptococcus pyogenes (EC 3.2.1.-)

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