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| Research article summary (published 30 Aug 2009): |
Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis.
Full Abstract
Germ cells, the cells that give rise to sperm and egg, maintain the potential to recreate all cell types in a new individual. This wide developmental potential, or totipotency, is manifested in unusual tumors called teratomas, in which germ cells undergo somatic differentiation. Although recent studies have implicated RNA regulation, the mechanism that normally prevents the loss of germ cell identity remains unexplained. In C. elegans, a teratoma is induced in the absence of the conserved RNA-binding protein GLD-1. Here, we demonstrate that GLD-1 represses translation of CYE-1/cyclin E during meiotic prophase, which prevents germ cells from re-entering mitosis and inducing embryonic-like transcription. We describe a mechanism that prevents precocious mitosis in germ cells undergoing meiosis, propose that this mechanism maintains germ cell identity by delaying the onset of embryonic gene activation until after fertilization, and provide a paradigm for the possible origin of human teratomas.
Author information
Author/s: Biedermann, Bjoern (B); Wright, Jane (J); Senften, Mathias (M); Kalchhauser, Irene (I); Sarathy, Gautham (G); Lee, Min-Ho (MH); Ciosk, Rafal (R);
Affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: Developmental cell (Dev Cell), published in United States. (Language: eng)
Reference: 2009-Sep; vol 17 (issue 3) : pp 355-64
Dates: Created 2009/09/17; Completed 2009/09/30;
PMID: 19758560, status: MEDLINE (last retrieval date: 9/30/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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