Investigating epigenetic influences on seizure disposition.

Full Abstract

Rats selectively bred to be seizure-prone versus resistant naturally exhibit behaviors, neuroanatomy and physiology that are reminiscent of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) in humans. Evidence suggests these characteristics evolve via genetic/epigenetic mechanisms acting prior to birth that most likely involve aberrant lipid handling.

Author information

Author/s: Gilby, Krista L (KL);

Affiliation: Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.

Journal and publication information

Publication Type: Journal Article

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci), published in Canada. (Language: eng)

Reference: 2009-Aug; vol 36 Suppl 2 (issue ) : pp S78-81

Dates: Created 2009/09/17; Completed 2009/11/02;

PMID: 19760910, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

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