A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives.

Full Abstract

The Israeli acute paralysis virus (IAPV) is a honeybee-infecting virus that was found to be associated with colony collapse disorder. The IAPV genome contains two genes encoding a structural and a nonstructural polyprotein. We applied a recently developed method for the estimation of selection in overlapping genes to detect purifying selection and, hence, functionality. We provide evolutionary evidence for the existence of a functional overlapping gene, which is translated in the +1 reading frame of the structural polyprotein gene. Conserved orthologs of this putative gene, which we provisionally call pog (predicted overlapping gene), were also found in the genomes of a monophyletic clade of dicistroviruses that includes IAPV, acute bee paralysis virus, Kashmir bee virus, and Solenopsis invicta (red imported fire ant) virus 1.

Author information

Author/s: Sabath, Niv (N); Price, Nicholas (N); Graur, Dan (D);

Affiliation: Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. nsabath(-atsign-)uh.edu

Grants: LM010009-01 (Agency:NLM NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Virology journal (Virol J), published in England. (Language: eng)

Reference: 2009-; vol 6 (issue ) : pp 144

Dates: Created 2009/09/30; Completed 2009/11/03;

PMID: 19761605, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

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