Core myopathies and risk of malignant hyperthermia.

Full Abstract

In this article, we analyze myopathies with cores, for which an association to malignant hyperthermia (MH) has been suggested. We discuss the clinical features, the underlying genetic defects, subsequent effects on cellular calcium metabolism, and in vitro muscle responses to MH triggers. We describe in detail central core disease, multiminicore disease, and nemaline rod myopathy. We categorize the diseases according to the affected proteins and discuss the risk for MH, which is high or theoretically possible when the calcium-conducting proteins are affected.

Author information

Author/s: Klingler, Werner (W); Rueffert, Henrik (H); Lehmann-Horn, Frank (F); Girard, Thierry (T); Hopkins, Philip M (PM);

Affiliation: Department of Anaesthesiology, University of Ulm, Ulm, Germany.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Anesthesia and analgesia (Anesth Analg), published in United States. (Language: eng)

Reference: 2009-Oct; vol 109 (issue 4) : pp 1167-73

Dates: Created 2009/09/18; Completed 2009/10/01;

PMID: 19762745, status: MEDLINE (last retrieval date: 10/1/2009, IMS Date: )

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