A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy.

Full Abstract

INTRODUCTION: In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain. METHODS: Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively. RESULTS: The accumulated oxycodone consumption was less (13.3 +/- 10.4 mg vs 22.0 +/- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006. CONCLUSIONS: Oxycodone was more potent than morphine for visceral pain relief but not for sedation.

Author information

Author/s: Lenz, Harald (H); Sandvik, Leiv (L); Qvigstad, Erik (E); Bjerkelund, Carl Eivind (CE); Raeder, Johan (J);

Affiliation: University of Oslo, Faculty Division Ullevaal University Hospital, Oslo, Norway. harald.lenz(-atsign-)medisin.uio.no

Journal and publication information

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Anesthesia and analgesia (Anesth Analg), published in United States. (Language: eng)

Reference: 2009-Oct; vol 109 (issue 4) : pp 1279-83

Dates: Created 2009/09/18; Completed 2009/10/01;

PMID: 19762758, status: MEDLINE (last retrieval date: 10/1/2009, IMS Date: )

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