Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence.

Full Abstract

To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragment-length polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.

Author information

Author/s: Middelkoop, Keren (K); Bekker, Linda-Gail (LG); Mathema, Barun (B); Shashkina, Elena (E); Kurepina, Natalia (N); Whitelaw, Andrew (A); Fallows, Dorothy (D); Morrow, Carl (C); Kreiswirth, Barry (B); Kaplan, Gilla (G); Wood, Robin (R);

Affiliation: Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Cape Town, South Africa. keren.middelkoop(-atsign-)hiv-research.org.za

Grants: 1U19AI05321 (Agency:NIAID NIH HHS) ; 1U19AI053217 (Agency:NIAID NIH HHS) ; R01 AI54361 (Agency:NIAID NIH HHS) ; R01 AI058736-02 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: The Journal of infectious diseases (J Infect Dis), published in United States. (Language: eng)

Reference: 2009-Oct; vol 200 (issue 8) : pp 1207-11

Dates: Created 2009/09/23; Completed 2009/10/29;

PMID: 19764885, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.