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| Research article summary (published 13 Oct 2009): |
Signature nucleotide polymorphisms at positions 64 and 65 in reverse transcriptase favor the selection of the K65R resistance mutation in HIV-1 subtype C.
Full Abstract
Recently, we described a novel nucleotide template-based mechanism that may be the basis for the facilitated acquisition of the K65R resistance mutation in subtype C versus subtype B human immunodeficiency virus type 1 (HIV-1). In this article, we evaluated the effects of subtype C-specific silent polymorphisms in cell culture drug-selection experiments using nucleoside and nucleotide reverse-transcriptase inhibitors. The K65R pathway was selected more frequently in a subtype B virus that contained subtype C nucleotide polymorphisms at both positions 64 and 65 than in a wild-type NL4-3 subtype B virus. This is the first demonstration of the significance of silent nucleotide polymorphisms in the development of drug resistance.
Author information
Author/s: Invernizzi, Cédric F (CF); Coutsinos, Dimitrios (D); Oliveira, Maureen (M); Moisi, Daniela (D); Brenner, Bluma G (BG); Wainberg, Mark A (MA);
Affiliation: McGill University AIDS Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Department of Medicine, McGill University, Montréal, Québec, Canada.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of infectious diseases (J Infect Dis), published in United States. (Language: eng)
Reference: 2009-Oct; vol 200 (issue 8) : pp 1202-6
Dates: Created 2009/09/23; Completed 2009/10/29;
PMID: 19764886, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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