Research article summary (published 29 Sep 2009):

Relation of high concentrations of plasma carboxy-terminal telopeptide of collagen type I with outcome in acute myocardial infarction.

Full Abstract

Acute myocardial infarction (AMI) is associated with matrix metalloproteinase activation. The plasma concentrations of carboxy-terminal telopeptide of collagen type I (CITP) reflect collagen type I degradation due to matrix metalloproteinase activation. We assessed the role of CITP as an early marker of outcome in AMI. Plasma CITP was measured 72 hours after hospital admission in 432 patients presenting with AMI. The 2 composite end points of the study (death, resuscitated cardiac arrest, recurrent AMI or ischemia, and heart failure or stroke; and death, resuscitated cardiac arrest, or heart failure) and mortality were assessed at 1 year in 4 patient groups stratified by the CITP quartiles. Patients with ST-segment elevation MI represented 75.7% of the population. In-hospital percutaneous coronary intervention was performed in 70.4% of the patients. The mean left ventricular ejection fraction was 53.9 +/- 12.5%. At 1 year of follow-up, high levels of CITP were associated with the occurrence of both composite end points and mortality (p <0.01 for all). Stepwise logistic regression analysis identified CITP as an independent predictor of both composite end points (odds ratio 2.14, 95% confidence interval 1.34 to 3.42, p = 0.001; and odds ratio 3.19, 95% confidence interval 1.50 to 6.81, p = 0.003), along with the Killip class and brain natriuretic peptide levels. In conclusion, high hospital levels of CITP, a marker of collagen degradation and ventricular remodeling, are associated with late mortality and other serious clinical events after AMI.

Author information

Author/s: Barthélémy, Olivier (O); Beygui, Farzin (F); Vicaut, Eric (E); Rouanet, Stephanie (S); Van Belle, Eric (E); Baulac, Cathrine (C); Degrandsart, Alexia (A); Dallongeville, Jean (J); Montalescot, Gilles (G); OPERA Investigators;

Affiliation: Institut de Cardiologie (APHP), INSERM U856 and University of Paris 6, Pitié-Salpétrière Hospital, Paris, France.

Journal and publication information

Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

Journal: The American journal of cardiology (Am J Cardiol), published in United States. (Language: eng)

Reference: 2009-Oct; vol 104 (issue 7) : pp 904-9

Dates: Created 2009/09/21; Completed 2009/10/06;

PMID: 19766754, status: MEDLINE (last retrieval date: 10/6/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Angioplasty, Transluminal, Percutaneous Coronary - methods; mortality Biological Markers - blood Cohort Studies Collagen Type I - blood Confidence Intervals Coronary Angiography Electrocardiography Female Follow-Up Studies France Humans Longitudinal Studies Male Middle Aged

Middle Aged Multivariate Analysis Myocardial Infarction - blood; diagnosis; mortality; therapy Natriuretic Peptide, Brain - blood Odds Ratio Peptide Fragments - blood Predictive Value of Tests Probability Procollagen - blood Prospective Studies Risk Assessment Severity of Illness Index Survival Rate Treatment Outcome Ventricular Remodeling - physiology

Associated Chemicals: Biological Markers (0) ; Collagen Type I (0) ; Peptide Fragments (0) ; Procollagen (0) ; procollagen type I carboxy terminal peptide (0) ; Natriuretic Peptide, Brain (114471-18-0)

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