Research article summary (published 30 Jul 2009):

Exercise-induced lymphocyte apoptosis attributable to cycle ergometer exercise in endurance-trained individuals.

Full Abstract

Exercise as a stimulus to induce lymphocyte apoptosis remains controversial. Differences may be due to participant fitness level or the methodology of assessing cell death. Another important issue is the mode of exercise used to induce physiological changes. Treadmill exercise typically induces significant apoptosis in human lymphocytes; however, the effect of cycle exercise is less clear. The 2 main purposes of this study were to assess if cycle ergometer exercise induces similar changes in apoptosis, and to further characterize the morphological method of assessing cell death. Endurance athletes (n = 10; peak oxygen consumption = 55.1 mL.kg-1.min-1) completed a 60-min ride on a cycle ergometer at approximately 80% peak oxygen consumption. Blood samples taken before (PRE) and after (POST) exercise were used to make blood films for apoptotic analysis via the morphological technique. A significant increase was observed in the apoptotic index following cycle exercise (PRE = 7.3 +/- 2%, POST = 12.9 +/- 2%; p < 0.01). On average, it took 42 +/- 9 min to read PRE sample slides, which was significantly longer than the 27 +/- 4 min needed for POST slides (p < 0.01). To our knowledge, this study is the first to report that exercise on the cycle ergometer produces changes in lymphocyte apoptosis. The values measured during this study were about 20% lower than those we have observed following treadmill running, which may be explained by differences in active muscle mass and the resultant physiological stress between the 2 exercise modes. It is likely that cycling may result in reduced immunosuppression, compared with running at the same intensity.

Author information

Author/s: Navalta, James Wilfred (JW); McFarlin, Brian Keith (BK); Lyons, Thomas Scott (TS); Faircloth, John Clifton (JC); Bacon, Nicholas T (NT); Callahan, Zachary J (ZJ);

Affiliation: Department of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY 42101, USA. james.navalta(-atsign-)wku.edu

Journal and publication information

Publication Type: Journal Article

Journal: Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme (Appl Physiol Nutr Metab), published in Canada. (Language: eng)

Reference: 2009-Aug; vol 34 (issue 4) : pp 603-8

Dates: Created 2009/09/21; Completed 2009/10/15;

PMID: 19767794, status: MEDLINE (last retrieval date: 10/15/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Apoptosis Bicycling Exercise Test Female Humans Immune Tolerance

Immune Tolerance Lymphocyte Count Lymphocytes - pathology Male Oxygen Consumption Physical Endurance Time Factors

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