Research article summary (published 20 Sep 2009):

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.

Full Abstract

BACKGROUND: While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role. In analyses of mice and cell cultures the gene has been found to be involved in the regulation of cholesterol synthesis; however, no relationship has been found with cholesterol metabolism in human epidemiological research. Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans. METHODS: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test. RESULTS: Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects. CONCLUSION: We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.

Author information

Author/s: Cha, Seongwon (S); Koo, Imhoi (I); Choi, Sun Mi (SM); Park, Byung Lae (BL); Kim, Kil Soo (KS); Kim, Jae-Ryong (JR); Shin, Hyoung Doo (HD); Kim, Jong Yeol (JY);

Affiliation: Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine, 483 Exporo, Daejeon, Republic of Korea. scha(-atsign-)kiom.re.kr

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: BMC medical genetics (BMC Med Genet), published in England. (Language: eng)

Reference: 2009-; vol 10 (issue ) : pp 96

Dates: Created 2009/10/12; Completed 2009/10/16;

PMID: 19772594, status: MEDLINE (last retrieval date: 10/16/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Asian Continental Ancestry Group Chi-Square Distribution Cholesterol - blood Female Genetic Predisposition to Disease Genotype Humans Intracellular Signaling Peptides and Proteins - genetics

Korea Male Membrane Proteins - genetics Middle Aged Obesity - blood; genetics Phenotype Polymorphism, Single Nucleotide Sex Factors Young Adult

Associated Chemicals: INSIG2 protein, human (0) ; Intracellular Signaling Peptides and Proteins (0) ; Membrane Proteins (0) ; Cholesterol (57-88-5)

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