Optimization of a novel procedure for determination of VOCs in water and human urine samples based on SBSE coupled with TD-GC-HRMS.

Full Abstract

In this study, stir-bar sorptive extraction and thermal desorption followed by gas chromatography coupled with high resolution mass spectrometry was applied for determination of halo-organic compounds (bromodichloromethane, dibromochloromethane, bromoform, and tetrachloroethylene) in water and human urine samples. Time of extraction and stirring speed were optimized. The results show that the optimum extraction time is 30 min with 600 rpm of stirring speed with Twister of 20 mm in length and 1.0-mm film thickness of PDMS (126 microL). The calibration curves, limits of detection and quantification for all compounds were calculated. This procedure is characterized by very low limits of detection and quantitation: lower than 0.0017 microg/L and good repeatability for all four volatile compounds. This new analytical procedure was identified to be easy, reliable, sensitive, and requires only small amounts of sample. It can constitute a good alternative to well-known procedures based on application of head space and gas chromatography coupled with electron capture detection.

Author information

Author/s: Jakubowska, Natalia (N); Henkelmann, Bernhard (B); Schramm, Karl-Werner (KW); Namiesnik, Jacek (J);

Affiliation: Department of Analytical Chemistry, Chemical Faculty, Gdánsk University of Technology (GUT), 80-952 Gdansk, Poland. nataliajakubowska26(-atsign-)wp.pl

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of chromatographic science (J Chromatogr Sci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 47 (issue 8) : pp 689-93

Dates: Created 2009/09/23; Completed 2009/10/27;

PMID: 19772746, status: MEDLINE (last retrieval date: 10/27/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Chemical Fractionation - methods
Chromatography, Gas - methods
Humans
Hydrocarbons, Halogenated - analysis; urine
Mass Spectrometry - methods

Reproducibility of Results
Tetrachloroethylene - analysis; urine
Trihalomethanes - analysis; urine
Volatile Organic Compounds - analysis; urine
Water Pollutants, Chemical - analysis

Associated Chemicals: Hydrocarbons, Halogenated (0) ; Trihalomethanes (0) ; Volatile Organic Compounds (0) ; Water Pollutants, Chemical (0) ; chlorodibromomethane (124-48-1) ; Tetrachloroethylene (127-18-4) ; bromoform (75-25-2) ; bromodichloromethane (75-27-4)

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