Research article summary (published 26 Sep 2009):

Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis.

Full Abstract

AIM: To investigate the inhibitory effect of natural taurine (NTau) on portal hypertension (PHT) in rats with experimentally-induced liver cirrhosis (LC). METHODS: Experimentally-induced LC Wistar rats (20 rats/group) were treated with either oral saline or oral NTau for 6 consecutive weeks. Evaluation parameters included portal venous pressure (PVP), portal venous resistance (PVR), portal venous flow (PVF), splanchnic vascular resistance (SVR) and mean arterial pressure (MAP). Vasoactive substance levels including nitric oxide (NO), nitric oxide synthase (NOS) and cyclic guanosine monophosphate (cGMP) were also measured. Histological investigation of type I and III collagen (COL I and III) and transforming growth factor-beta(1) (TGF-beta1) was also performed. RESULTS: Treatment with NTau (1) significantly decreased PVP, PVR and PVF, and increased MAP and SVP; (2) markedly increased the vascular compliance and reduced the zero-stress of the portal vein; (3) markedly decreased the amount of NO and cGMP and activity of NOS; and (4) improved the pathological status of the liver tissue and reduced the expression of COL I, COL III and TGF-beta1. CONCLUSION: NTau inhibited the LC-induced PHT by improving hyperdynamic circulation, morphology of liver and biomechanical properties of the portal vein in experimentally-induced LC rats.

Author information

Author/s: Liang, Jian (J); Deng, Xin (X); Lin, Zhi-Xiu (ZX); Zhao, Li-Chun (LC); Zhang, Xi-Liu (XL);

Affiliation: The Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical College, Nanning 530011, Guangxi Zhuang Autonomous Region, China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: World journal of gastroenterology : WJG (World J Gastroenterol), published in China. (Language: eng)

Reference: 2009-Sep; vol 15 (issue 36) : pp 4529-37

Dates: Created 2009/09/24; Completed 2009/11/03;

PMID: 19777611, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Biomechanics - drug effects Collagen Type I - metabolism Collagen Type III - metabolism Cyclic GMP - metabolism Hemodynamics - drug effects Hepatic Stellate Cells - metabolism Hypertension, Portal - drug therapy; etiology; metabolism

Liver Cirrhosis, Experimental - complications; drug therapy; metabolism Male Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Rats Rats, Wistar Taurine - therapeutic use Transforming Growth Factor beta - metabolism

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; Transforming Growth Factor beta (0) ; Nitric Oxide (10102-43-9) ; Taurine (107-35-7) ; Cyclic GMP (7665-99-8) ; Nitric Oxide Synthase (EC 1.14.13.39)

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