Research article summary (published 26 Sep 2009):

Lack of correlation between p53 codon 72 polymorphism and anal cancer risk.

Full Abstract

AIM: To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS: Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study. p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS: The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION: These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis.

Author information

Author/s: Contu, Simone S (SS); Agnes, Grasiela (G); Damin, Andrea P (AP); Contu, Paulo C (PC); Rosito, Mário A (MA); Alexandre, Claudio O (CO); Damin, Daniel C (DC);

Affiliation: Department of Surgery, Division of Coloproctology, Clinicas Hospital of Porto Alegre and Federal University of Rio Grande do Sul, 90.035-930 Porto Alegre, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: World journal of gastroenterology : WJG (World J Gastroenterol), published in China. (Language: eng)

Reference: 2009-Sep; vol 15 (issue 36) : pp 4566-70

Dates: Created 2009/09/24; Completed 2009/11/03;

PMID: 19777616, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Aged, 80 and over Anus Neoplasms - epidemiology; genetics Codon Female Gene Frequency Genes, p53

Genes, p53 Humans Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Risk Factors Statistics as Topic

Associated Chemicals: Codon (0)

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