The neurobiology of decision: consensus and controversy.

Full Abstract

We review and synthesize recent neurophysiological studies of decision making in humans and nonhuman primates. From these studies, the basic outline of the neurobiological mechanism for primate choice is beginning to emerge. The identified mechanism is now known to include a multicomponent valuation stage, implemented in ventromedial prefrontal cortex and associated parts of striatum, and a choice stage, implemented in lateral prefrontal and parietal areas. Neurobiological studies of decision making are beginning to enhance our understanding of economic and social behavior as well as our understanding of significant health disorders where people's behavior plays a key role.

Author information

Author/s: Kable, Joseph W (JW); Glimcher, Paul W (PW);

Affiliation: Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. kable(-atsign-)psych.upenn.edu

Grants: R01-EY010536 (Agency:NEI NIH HHS) ; R01-NS054775 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2009-Sep; vol 63 (issue 6) : pp 733-45

Dates: Created 2009/09/25; Completed 2009/10/09; Revised 2009/10/23;

PMID: 19778504, status: MEDLINE (last retrieval date: 10/26/2009, IMS Date: )

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