Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration.

Full Abstract

Throughout the brain, multiple interneuron types influence distinct aspects of synaptic processing. Interneuron diversity can thereby promote differential firing from neurons receiving common excitation. In contrast, Golgi cells are the sole interneurons regulating granule cell spiking evoked by mossy fibers, thereby gating inputs to the cerebellar cortex. Here, we examine how this single interneuron class modifies activity in its targets. We find that GABA(A)-mediated transmission at unitary Golgi cell --> granule cell synapses consists of varying contributions of fast synaptic currents and sustained inhibition. Fast IPSCs depress and slow IPSCs gradually build during high-frequency Golgi cell activity. Consequently, fast and slow inhibition differentially influence granule cell spike timing during persistent mossy fiber input. Furthermore, slow inhibition reduces the gain of the mossy fiber --> granule cell input-output curve, while fast inhibition increases the threshold. Thus, a lack of interneuron diversity need not prevent flexible inhibitory control of synaptic processing.

Author information

Author/s: Crowley, John J (JJ); Fioravante, Diasynou (D); Regehr, Wade G (WG);

Affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

Grants: R37 NS032405 (Agency:NINDS NIH HHS) ; T32NS007484 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2009-Sep; vol 63 (issue 6) : pp 843-53

Dates: Created 2009/09/25; Completed 2009/10/09;

PMID: 19778512, status: MEDLINE (last retrieval date: 10/9/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Neuron. 2009 Sep 24;63(6):716-8. (PMID: 19778499)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - drug effects; physiology
Animals
Animals, Newborn
Biophysics
Cell Line, Transformed
Cerebellum - cytology
Electric Stimulation - methods
Excitatory Amino Acid Antagonists - pharmacology
GABA Antagonists - pharmacology
Humans
Inhibitory Postsynaptic Potentials - drug effects; physiology
Neural Inhibition - drug effects; physiology
Neurons - classification; drug effects; physiology

Associated Chemicals: Excitatory Amino Acid Antagonists (0) ; GABA Antagonists (0) ; Phosphinic Acids (0) ; Piperazines (0) ; Propanolamines (0) ; Quinoxalines (0) ; 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (100828-16-8) ; 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline (118876-58-7) ; CGP 55845A (148056-42-2) ; Rhodopsin (9009-81-8)

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