Formation of spatial memory in rats with ischemic lesions to the prefrontal cortex; effects of a synthetic analog of ACTH(4-7).

Full Abstract

Photochemically induced thrombosis of blood vessels in the prefrontal cortex in rats was shown to lead to ischemic infarcts in the lesion zone. Bilateral ischemic lesioning of the prefrontal cortex degraded measures of spatial memory when animals were tested in a Morris water maze with an invisible platform 20-24 days after surgery. Chronic intranasal administration of the peptide Met-Glu-His-Phe-Pro-Gly-Pro (Semax), a synthetic analog of ACTH(4-7), at a dose of 250 microg/kg/day during the first six days after photothrombosis, led to recovery of the animals' learning ability. The long-term antiamnestic action of the peptide observed here may result from its neuroprotective activity and its ability to stimulate the synthesis of neurotrophic factors.

Author information

Author/s: Silachev, D N (DN); Shram, S I (SI); Shakova, F M (FM); Romanova, G A (GA); Myasoedov, N F (NF);

Affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia. proteins(-atsign-)mail.ru

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroscience and behavioral physiology (Neurosci Behav Physiol), published in United States. (Language: eng)

Reference: 2009-Oct; vol 39 (issue 8) : pp 749-56

Dates: Created 2009/09/25; Completed 2009/10/05;

PMID: 19779827, status: MEDLINE (last retrieval date: 10/5/2009, IMS Date: )

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