Research article summary (published 13 Oct 2009):

Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.

Full Abstract

Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

Author information

Author/s: Kim, Juwon (J); Park, Tae Sung (TS); Song, Jaewoo (J); Lee, Kyung-A (KA); Hong, Duk Jin (DJ); Min, Yoo Hong (YH); Cheong, June-Won (JW); Choi, Jong Rak (JR);

Affiliation: Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet), published in United States. (Language: eng)

Reference: 2009-Oct; vol 194 (issue 2) : pp 111-8

Dates: Created 2009/09/28; Completed 2009/10/08;

PMID: 19781443, status: MEDLINE (last retrieval date: 10/8/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Base Sequence Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 21 Cytogenetic Analysis DNA Mutational Analysis Female

Female Humans Leukemia, Myeloid, Acute - genetics; pathology Male Oncogene Proteins, Fusion - genetics; isolation & purification RNA, Messenger - genetics; isolation & purification RNA-Binding Protein FUS - genetics; isolation & purification Translocation, Genetic

Associated Chemicals: Oncogene Proteins, Fusion (0) ; RNA, Messenger (0) ; RNA-Binding Protein FUS (0) ; TLS-ERG fusion protein, human (0)

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