Research article summary (published 22 Sep 2009):

The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability.

Full Abstract

In this issue of Molecular Cell, Fabian et al. (2009) demonstrate that in cell-free extracts from mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors required for deadenylation.

Author information

Author/s: Omer, Arina D (AD); Janas, Maja M (MM); Novina, Carl D (CD);

Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Journal and publication information

Publication Type: Comment; Journal Article

Journal: Molecular cell (Mol Cell), published in United States. (Language: eng)

Reference: 2009-Sep; vol 35 (issue 6) : pp 739-40

Dates: Created 2009/09/28; Completed 2009/10/08;

PMID: 19782024, status: MEDLINE (last retrieval date: 10/8/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentOn: Mol Cell. 2009 Sep 24;35(6):868-80. (PMID: 19716330)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Ascites - genetics; metabolism Autoantigens - metabolism Binding Sites Carcinoma, Krebs 2 - genetics; metabolism Eukaryotic Initiation Factor-2 - metabolism Eukaryotic Initiation Factor-4G - metabolism Gene Silencing Humans Kinetics Mice

Mice MicroRNAs - metabolism Poly(A)-Binding Proteins - genetics; metabolism Protein Biosynthesis Protein Structure, Tertiary Proteins - genetics; metabolism RNA Processing, Post-Transcriptional RNA Stability RNA, Messenger - metabolism RNA-Induced Silencing Complex - genetics; metabolism Receptors, CCR4 - metabolism

Associated Chemicals: Autoantigens (0) ; Ccr4 protein, mouse (0) ; Cnot7 protein, mouse (0) ; EIF2C2 protein, mouse (0) ; Eukaryotic Initiation Factor-2 (0) ; Eukaryotic Initiation Factor-4G (0) ; MicroRNAs (0) ; Poly(A)-Binding Proteins (0) ; Proteins (0) ; RNA, Messenger (0) ; RNA-Induced Silencing Complex (0) ; Receptors, CCR4 (0) ; mirnlet7 microRNA, mouse (0)

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