Polyunsaturated fatty acid status in attention deficit hyperactivity disorder, depression, and Alzheimer's disease: towards an omega-3 index for mental health?

Full Abstract

Interest in the role of polyunsaturated fatty acids (PUFAs), particularly long-chain (LC) omega-3 (n-3) PUFAs, in mental health is increasing. This review investigates whether n-3 PUFA levels are abnormal in people with three prevalent mental health problems - attention deficit hyperactivity disorder, depression, and dementia. Data sources included PubMed, Web of Science, and bibliographies of papers published in English that describe PUFA levels in the circulation of individuals who have these mental health conditions. Although abnormal blood PUFA levels were reported in a number of studies, weighted comparisons of PUFA status showed no significant differences overall between people with mental health problems and controls. Whether those with low n-3 PUFA status are likely to be more responsive to n-3 PUFA supplementation is not yet resolved. Further studies assessing PUFA levels and mental status with greater uniformity are required in order to clarify the relationship between LC n-3 PUFA status and mental health.

Author information

Author/s: Milte, Catherine M (CM); Sinn, Natalie (N); Howe, Peter R C (PR);

Affiliation: Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia. catherine.milte(-atsign-)unisa.edu.au

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Nutrition reviews (Nutr Rev), published in United States. (Language: eng)

Reference: 2009-Oct; vol 67 (issue 10) : pp 573-90

Dates: Created 2009/09/29; Completed 2009/11/06;

PMID: 19785689, status: MEDLINE (last retrieval date: 11/6/2009, IMS Date: )

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