Research article summary (published 27 Sep 2009):

Microsatellite based genetic diversity and population structure of the endangered Spanish Guadarrama goat breed.

Full Abstract

BACKGROUND: Assessing genetic biodiversity and population structure of minor breeds through the information provided by neutral molecular markers, allows determination of their extinction risk and to design strategies for their management and conservation. Analysis of microsatellite loci is known to be highly informative in the reconstruction of the historical processes underlying the evolution and differentiation of animal populations. Guadarrama goat is a threatened Spanish breed which actual census (2008) consists of 3057 females and 203 males distributed in 22 populations more or less isolated. The aim of this work is to study the genetic status of this breed through the analysis of molecular data from 10 microsatellites typed in historic and actual live animals. RESULTS: The mean expected heterozygosity across loci within populations ranged from 0.62 to 0.77. Genetic differentiation measures were moderate, with a mean FST of 0.074, GST of 0.081 and RST of 0.085. Percentages of variation among and within populations were 7.5 and 92.5, respectively. Bayesian clustering analyses pointed out a population subdivision in 16 clusters, however, no correlation between geographical distances and genetic differences was found. Management factors such as the limited exchange of animals between farmers (estimated gene flow Nm = 3.08) mostly due to sanitary and social constraints could be the major causes affecting Guadarrama goat population subdivision. CONCLUSION: Genetic diversity measures revealed a good status of biodiversity in the Guadarrama goat breed. Since diseases are the first cause affecting the census in this breed, population subdivision would be an advantage for its conservation. However, to maintain private alleles present at low frequencies in such small populations minimizing the inbreeding rate, it would necessitate some mating designs of animals carrying such alleles among populations. The systematic use of molecular markers will facilitate the comprehensive management of these populations, which in combination with the actual breeding program to increase milk yield, will constitute a good strategy to preserve the breed.

Author information

Author/s: Serrano, Magdalena (M); Calvo, Jorge H (JH); Martínez, Marta (M); Marcos-Carcavilla, Ane (A); Cuevas, Javier (J); González, Carmen (C); Jurado, Juan J (JJ); de Tejada, Paloma Díez (PD);

Affiliation: Departamento de Mejora Genética Animal, INIA, 28080 Madrid, Spain. malena(-atsign-)inia.es

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: BMC genetics (BMC Genet), published in England. (Language: eng)

Reference: 2009-; vol 10 (issue ) : pp 61

Dates: Created 2009/10/15; Completed 2009/11/02;

PMID: 19785776, status: MEDLINE (last retrieval date: 11/2/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alleles Animals Bayes Theorem Breeding Cluster Analysis Conservation of Natural Resources Gene Frequency

Genetic Variation Genetics, Population Goats - genetics Heterozygote Microsatellite Repeats Sequence Analysis, DNA Spain

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