Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors.

Full Abstract

OBJECTIVE: This study investigated neonatal S100B levels as a biomarker of prenatal selective serotonin reuptake inhibitor (SSRI) exposure. METHODS: Maternal (delivery; N = 53) and neonatal (cord; N = 52) serum S100B levels were compared between prenatally SSRI-exposed (maternal, N = 36; neonatal, N = 37; duration: 230 +/- 71 days) and nonexposed (maternal, N = 17; neonatal, N = 15) groups. Measures of maternal depression and anxiety symptoms were assessed during the third trimester (33-36 weeks), and neonatal outcomes, including Apgar scores, birth weight, gestational age at birth, and symptoms of poor neonatal adaptation, were recorded. RESULTS: S100B levels were significantly lower in prenatally SSRI-exposed neonates than in nonexposed neonates, controlling for gestational age and third-trimester maternal mood (P = .036). In contrast, SSRI-exposed mothers had significantly higher maternal serum S100B levels, compared with nonexposed mothers (P = .014), even controlling for maternal mood in the third trimester. S100B levels were not associated with maternal or neonatal drug levels, duration of prenatal exposure, demographic variables, or risk for poor neonatal adaptation. CONCLUSIONS: Prenatal SSRI exposure was associated with decreased neonatal serum S100B levels, controlling for prenatal maternal mood. Neonatal S100B levels did not reflect neonatal behavioral outcomes and were not related to pharmacologic indices. These findings are consistent with prenatal alcohol and cocaine exposures, which also alter central serotonin levels.

Author information

Author/s: Pawluski, Jodi L (JL); Galea, Liisa A M (LA); Brain, Ursula (U); Papsdorf, Michael (M); Oberlander, Tim F (TF);

Affiliation: Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Pediatrics (Pediatrics), published in United States. (Language: eng)

Reference: 2009-Oct; vol 124 (issue 4) : pp e662-70

Dates: Created 2009/09/29; Completed 2009/10/23;

PMID: 19786426, status: MEDLINE (last retrieval date: 10/23/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Biological Markers - blood
Confidence Intervals
Depressive Disorder - blood; drug therapy
Female
Fetal Blood - chemistry
Humans
Infant, Newborn
Longitudinal Studies
Male
Maternal Exposure - adverse effects
Maternal-Fetal Exchange - drug effects

Nerve Growth Factors - blood
Pregnancy
Pregnancy Complications - blood; drug therapy
Pregnancy Outcome
Pregnancy Trimester, Second
Prenatal Diagnosis
Prenatal Exposure Delayed Effects - blood
Probability
Prospective Studies
Risk Assessment
S100 Proteins - blood
Serotonin Uptake Inhibitors - administration & dosage; adverse effects

Associated Chemicals: Biological Markers (0) ; Nerve Growth Factors (0) ; S-100 calcium-binding protein beta subunit (0) ; S100 Proteins (0) ; Serotonin Uptake Inhibitors (0)

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