Research article summary (published 4 Oct 2009):

Salivary analysis of oral cancer biomarkers.

Full Abstract

BACKGROUND: Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing. METHODS: We tested 19 tongue cancer patients, measuring the levels of 8 salivary markers related to oxidative stress, DNA repair, carcinogenesis, metastasis and cellular proliferation and death. RESULTS: Five markers increased in cancer patients by 39-246%: carbonyls, lactate dehydrogenase, metalloproteinase-9 (MMP-9), Ki67 and Cyclin D1 (CycD1) (P< or =0.01). Three markers decreased by 16-29%: 8-oxoguanine DNA glycosylase, phosphorylated-Src and mammary serine protease inhibitor (Maspin) (P< or =0.01). Increase in salivary carbonyls was profound (by 246%, P=0.012); alterations in CycD1 (87% increase, P=0.000006) and Maspin (29% decrease, P=0.007) were especially significant. Sensitivity values of these eight analysed markers ranged from 58% to 100%; specificity values ranged from 42% to 100%. Both values were especially high for the CycD1 and Maspin markers, 100% for each value of each marker. These were also high for carbonyls, 90% and 80%, respectively, and for MMP-9, 100% and 79%, respectively. CONCLUSION: The significance of each salivary alteration is discussed. As all alterations correlated with each other, they may belong to a single carcinogenetic network. Cancer-related changes in salivary tumour markers may be used as a diagnostic tool for diagnosis, prognosis and post-operative monitoring.

Author information

Author/s: Shpitzer, T (T); Hamzany, Y (Y); Bahar, G (G); Feinmesser, R (R); Savulescu, D (D); Borovoi, I (I); Gavish, M (M); Nagler, R M (RM);

Affiliation: Department of Otorhinolaryngology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Journal and publication information

Publication Type: Journal Article

Journal: British journal of cancer (Br J Cancer), published in England. (Language: eng)

Reference: 2009-Oct; vol 101 (issue 7) : pp 1194-8

Dates: Created 2009/09/30; Completed 2009/10/14; Revised 2009/10/28;

PMID: 19789535, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - diagnosis Cyclin D1 - analysis DNA Glycosylases - analysis Female Humans Ki-67 Antigen - analysis

Ki-67 Antigen - analysis Male Matrix Metalloproteinase 9 - analysis Middle Aged Neoplasm Staging Saliva - chemistry Sensitivity and Specificity Tongue Neoplasms - diagnosis; pathology Tumor Markers, Biological - analysis

Associated Chemicals: CCND1 protein, human (0) ; Ki-67 Antigen (0) ; Tumor Markers, Biological (0) ; Cyclin D1 (136601-57-5) ; DNA Glycosylases (EC 3.2.2.-) ; oxoguanine glycosylase 1, human (EC 3.2.2.-) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)

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