Is there more to aging than mitochondrial DNA and reactive oxygen species?

Full Abstract

With the aging of the population, we are seeing a global increase in the prevalence of age-related disorders, especially in developed countries. Chronic diseases disproportionately affect the older segment of the population, contributing to disability, a diminished quality of life and an increase in healthcare costs. Increased life expectancy reflects the success of contemporary medicine, which must now respond to the challenges created by this achievement, including the growing burden of chronic illnesses, injuries and disabilities. A well-developed theoretical framework is required to understand the molecular basis of aging. Such a framework is a prerequisite for the development of clinical interventions that will constitute an efficient response to the challenge of age-related health issues. This review critically analyzes the experimental evidence that supports and refutes the Free Radical/Mitochondrial Theory of Aging, which has dominated the field of aging research for almost half a century.

Author information

Author/s: Alexeyev, Mikhail F (MF);

Affiliation: Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, AL 36688, USA. malexeye(-atsign-)jaguar1.usouthal.edu

Grants: P01 HL06629907 (Agency:NHLBI NIH HHS) ; R21RR02396101 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

Journal: The FEBS journal (FEBS J), published in England. (Language: eng)

Reference: 2009-Oct; vol 276 (issue 20) : pp 5768-87

Dates: Created 2009/10/02; Completed 2009/10/20;

PMID: 19796285, status: MEDLINE (last retrieval date: 10/20/2009, IMS Date: )

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