A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin.

Full Abstract

Malignant melanomas are aggressive tumors that are largely refractory to conventional drug therapies. A recent study reported in Nature Genetics identified mutationally activated ErbB4 alleles in 20% of cases. These tumor cells exhibit ErbB4 dependency, suggesting that ErbB4 kinase inhibition may constitute an effective therapeutic strategy in this setting.

Author information

Author/s: Settleman, Jeff (J);

Affiliation: Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA. settleman(-atsign-)helix.mgh.harvard.edu

Journal and publication information

Publication Type: Journal Article

Journal: Cancer cell (Cancer Cell), published in United States. (Language: eng)

Reference: 2009-Oct; vol 16 (issue 4) : pp 278-9

Dates: Created 2009/10/05; Completed 2009/10/15;

PMID: 19800573, status: MEDLINE (last retrieval date: 10/15/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Melanoma - drug therapy; genetics; metabolism; pathology
Mutation
Phenotype
Protein Kinase Inhibitors - pharmacology
Receptor, Epidermal Growth Factor - antagonists & inhibitors; genetics; metabolism
Skin Neoplasms - drug therapy; genetics; metabolism; pathology

Associated Chemicals: Antineoplastic Agents (0) ; Protein Kinase Inhibitors (0) ; ERBB4 protein (EC 2.7.1.112) ; Receptor, Epidermal Growth Factor (EC 2.7.1.112)

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