Research article summary (published 30 Sep 2009):

The phosphatase SHP2 regulates the spacing effect for long-term memory induction.

Full Abstract

A property of long-term memory (LTM) induction is the requirement for repeated training sessions spaced over time. This augmentation of memory formation with spaced resting intervals is called the spacing effect. We now show that in Drosophila, the duration of resting intervals required for inducing LTM is regulated by activity levels of the protein tyrosine phosphatase corkscrew (CSW). Overexpression of wild-type CSW in mushroom body neurons shortens the inter-trial interval required for LTM induction, whereas overexpression of constitutively active CSW proteins prolongs these resting intervals. These gain-of-function csw mutations are associated with a clinical condition of mental retardation. Biochemical analysis reveals that LTM-inducing training regimens generate repetitive waves of CSW-dependent MAPK activation, the length of which appears to define the duration of the resting interval. Constitutively active CSW proteins prolong the resting interval by altering the MAPK inactivation cycle. We thus provide insight into the molecular basis of the spacing effect.

Author information

Author/s: Pagani, Mario R (MR); Oishi, Kimihiko (K); Gelb, Bruce D (BD); Zhong, Yi (Y);

Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Grants: 5R01 DC05784-05A1 (Agency:NIDCD NIH HHS) ; HL 71207 (Agency:NHLBI NIH HHS) ; R01 DC005784-05 (Agency:NIDCD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Cell (Cell), published in United States. (Language: eng)

Reference: 2009-Oct; vol 139 (issue 1) : pp 186-98

Dates: Created 2009/10/06; Completed 2009/10/27; Revised 2009/11/03;

PMID: 19804763, status: MEDLINE (last retrieval date: 11/4/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Cell. 2009 Oct 2;139(1):23-5. (PMID: 19804749)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Drosophila Proteins - metabolism Humans Learning MAP Kinase Signaling System Memory

Memory Mushroom Bodies - cytology; metabolism Neurons - metabolism Protein Tyrosine Phosphatases, Non-Receptor - metabolism Signal Transduction Transgenes

Associated Chemicals: Drosophila Proteins (0) ; Protein Tyrosine Phosphatases, Non-Receptor (EC 3.1.3.48) ; corkscrew protein, Drosophila (EC 3.1.3.48)

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