Enhanced SnapShot: Antibiotic inhibition of protein synthesis II.

Full Abstract

The translational apparatus is one of the major targets for antibiotics in the bacterial cell. Antibiotics predominantly interact with the functional centers of the ribosome, namely the messenger RNA (mRNA)-transfer RNA (tRNA) decoding region on the 30S subunit, the peptidyltransferase center on the 50S subunit, or the ribosomal exit tunnel through which the nascent polypeptide chain passes during translation. Protein synthesis can be divided into three phases: initiation, elongation, and termination/recycling.

Author information

Author/s: Sohmen, Daniel (D); Harms, Joerg M (JM); Schlünzen, Frank (F); Wilson, Daniel N (DN);

Affiliation: University of Munich, Germany.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Cell (Cell), published in United States. (Language: eng)

Reference: 2009-Oct; vol 139 (issue 1) : pp 212-212.e1

Dates: Created 2009/10/06; Completed 2009/10/27;

PMID: 19804764, status: MEDLINE (last retrieval date: 10/27/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Anti-Bacterial Agents - pharmacology
Bacteria - drug effects; genetics; metabolism
Bacterial Proteins - metabolism
Protein Biosynthesis - drug effects

Associated Chemicals: Anti-Bacterial Agents (0) ; Bacterial Proteins (0) ; RNA, Bacterial (0) ; Ribosomal Proteins (0) ; RNA, Transfer (9014-25-9)

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