KLF family members regulate intrinsic axon regeneration ability.

Full Abstract

Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons. RGCs lacking KLF4 showed increased axon growth both in vitro and after optic nerve injury in vivo. Related KLF family members suppressed or enhanced axon growth to differing extents, and several growth-suppressive KLFs were up-regulated postnatally, whereas growth-enhancing KLFs were down-regulated. Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons.

Author information

Author/s: Moore, Darcie L (DL); Blackmore, Murray G (MG); Hu, Ying (Y); Kaestner, Klaus H (KH); Bixby, John L (JL); Lemmon, Vance P (VP); Goldberg, Jeffrey L (JL);

Affiliation: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Grants: P30 EY014801 (Agency:NEI NIH HHS) ; R01 NS061348 (Agency:NINDS NIH HHS) ; R03 EY016790 (Agency:NEI NIH HHS) ; T32 NS007459 (Agency:NINDS NIH HHS) ; T32 NS07492 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)

Reference: 2009-Oct; vol 326 (issue 5950) : pp 298-301

Dates: Created 2009/10/09; Completed 2009/10/19;

PMID: 19815778, status: MEDLINE (last retrieval date: 10/19/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Science. 2009 Oct 9;326(5950):238-9. (PMID: 19815761)

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