Rotavirus gastroenteritis in children in 4 regions in Brazil: a hospital-based surveillance study.

Full Abstract

BACKGROUND: Rotavirus is a major cause of gastroenteritis in children. Knowledge of rotavirus genotypes is important for vaccination strategies. METHODS: During 2005-2006, rotavirus surveillance studies were conducted in São Paulo, Salvador, Goiânia, and Porto Alegre, Brazil. Stool samples were collected from children <5 years of age who had diarrhea and were screened by the Rotaclone Enzyme Immunoassay for the presence of rotavirus. Confirmed rotavirus-positive samples were characterized for P and G genotypes by reverse-transcriptase polymerase chain reaction. RESULTS: A total of 510 stool samples were collected. Of these, 221 (43.3%) were positive for rotavirus. Overall, G9 was the predominant G type, followed by G2, and G1; P[4] and P[8] were the predominant P types. The most frequent G/P genotype combination detected was G2P[4], followed by G9P[8], G9P[4], and G1P[8]. G2P[4] was the predominant type in Goiânia and Salvador; G9P[8] and G1P[8] were predominant in São Paulo and Porto Alegre, respectively. CONCLUSIONS: The prevalence, seasonality, and genotype distribution of rotavirus infection varied in different regions in Brazil. With immunization programs, continuous monitoring of rotavirus types is important to detect novel and emerging strains.

Author information

Author/s: Munford, Veridiana (V); Gilio, Alfredo Elias (AE); de Souza, Eloisa Correa (EC); Cardoso, Debora Morais (DM); Cardoso, Divina das Dores de Paula (DD); Borges, Ana Maria Tavares (AM); Costa, Paulo Sergio Sucasas da (PS); Melgaço, Irene Angela Melo (IA); Rosa, Humberto (H); Carvalho, Paulo Roberto Antonacci (PR); Goldani, Marcelo Zubaran (MZ); Moreira, Edson Duarte (ED); Santana, Ciria (C); El Khoury, Antoine (A); Ikedo, Fabio (F); Rácz, Maria Lucia (ML);

Affiliation: Virology Laboratories, Department of Microbiology, Institute of Biomedical Sciences, MSD Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of infectious diseases (J Infect Dis), published in United States. (Language: eng)

Reference: 2009-Nov; vol 200 Suppl 1 (issue ) : pp S106-13

Dates: Created 2009/10/12; Completed 2009/11/03;

PMID: 19817590, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

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