Molecular epidemiology of rotavirus diarrhea among children aged <5 years in nepal: predominance of emergent G12 strains during 2 years.

Full Abstract

A 2-year surveillance was performed in Kathmandu, Nepal, by collection of stool specimens from 1139 children aged <5 years who were hospitalized for acute diarrhea from November 2005 through October 2007. Of the 1139 samples, 379 (33%) had rotavirus strains identified by enzyme-linked immunosorbent assay; the most prevalent G type was G12, accounting for 50% of typed strains in 2005-2006 and 29% in 2006-2007, followed by G1 (26%) in 2005-2006 and by G9 (28%) and G2 (20%) in 2006-2007. The most prevalent P type was P[8], accounting for 47% of strains in 2005-2006 and 35% in 2006-2007, followed by P[6] (37% in 2005-2006 and 33% in 2006-2007) and P[4] (10% in 2005-2006 and 24% in 2006-2007). Of combined genotypes, G12P[6] was the most prevalent, accounting for 34% of strains in 2005-2006 and 24% in 2006-2007, followed by G1P[8] (23%) in 2005-2006 and G2P[4] (20%) in 2006-2007. An unusually high detection of G12 strains underscores the importance of continued surveillance of rotavirus strains.

Author information

Author/s: Sherchand, Jeevan Bahadur (JB); Nakagomi, Osamu (O); Dove, Winifred (W); Nakagomi, Toyoko (T); Yokoo, Michiyo (M); Pandey, Basu Dev (BD); Cuevas, Luis E (LE); Hart, C Anthony (CA); Cunliffe, Nigel A (NA);

Affiliation: Department of Clinical Microbiology and Health Research Laboratory, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of infectious diseases (J Infect Dis), published in United States. (Language: eng)

Reference: 2009-Nov; vol 200 Suppl 1 (issue ) : pp S182-7

Dates: Created 2009/10/12; Completed 2009/11/03;

PMID: 19817599, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

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