G and P types of circulating rotavirus strains in the United States during 1996-2005: nine years of prevaccine data.

Full Abstract

BACKGROUND: Rotavirus vaccine was recommended for routine use among US infants in 2006. To provide prevaccine data, we conducted strain surveillance for 9 consecutive seasons during 1996-2005. METHODS: Using reverse-transcriptase polymerase chain reaction genotyping and nucleotide sequencing, we determined P/G genotypes of >3100 rotavirus strains collected in up to 12 cities each year from different US regions. RESULTS: The most prevalent strain globally, P[8] G1, was the most prevalent each year in the United States (overall, 78.5% of strains; range, 60.0%-93.9%), and 9.2% of the samples were P[4] G2, 3.6% were P[8] G9, 1.7% were P[8] G3, and 0.8% were P[8] G4. Genotype P[6] G9, which emerged in 1995, was detected continuously for several seasons (from 1996-1997 to 2000-2001, 0.2%-5.4%) but was not identified in the subsequent 4 seasons. Single or a few detections of rare genotypes (eg, P[6] G12, P[9] G6, and P[9] G3) were observed during several rotavirus seasons at frequencies of 0.5%-1.7% and, overall, comprised 0.6% of all the samples from the entire surveillance period. Several globally common strains in addition to G1, especially G2 and G9, circulated at high prevalence (33%-62%) in some cities during certain years. CONCLUSIONS: Almost 85% of strains during 1996-2005 had either a G or P antigen that is present in both RotaTeq (Merck) and Rotarix (GlaxoSmithKline). Monitoring of strains after introduction of rotavirus vaccines is important.

Author information

Author/s: Gentsch, Jon R (JR); Hull, Jennifer J (JJ); Teel, Elizabeth N (EN); Kerin, Tara K (TK); Freeman, Molly M (MM); Esona, Mathew D (MD); Griffin, Dixie D (DD); Bielfelt-Krall, Brittany P (BP); Banyai, Krisztian (K); Jiang, Baoming (B); Cortese, Margaret M (MM); Glass, Roger I (RI); Parashar, Umesh D (UD); collaborating laboratories of the National Rotavirus Strain Surveillance System;

Affiliation: Gastroenteritis and Respiratory Viruses Laboratory Branch, Atlanta, Georgia. jrg4(-atsign-)cdc.gov

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: The Journal of infectious diseases (J Infect Dis), published in United States. (Language: eng)

Reference: 2009-Nov; vol 200 Suppl 1 (issue ) : pp S99-S105

Dates: Created 2009/10/12; Completed 2009/11/03;

PMID: 19817622, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

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