Structure of yellow fever virus envelope protein domain III.

Full Abstract

The structure of recombinant domain III of the envelope protein (rED3) of yellow fever virus (YFV), containing the major neutralization site, was determined using NMR spectroscopy. The amino acid sequence and structure of the YFV-rED3 shows differences from ED3s of other mosquito-borne flaviviruses; in particular, the partially surface-exposed BC loop where methionine-304 and valine-324 were identified as being critical for the structure of the loop. Variations in the structure and surface chemistry of ED3 between flaviviruses affect neutralization sites and may affect host cell receptor interactions and play a role in the observed variations in viral pathogenesis and tissue tropism.

Author information

Author/s: Volk, David E (DE); May, Fiona J (FJ); Gandham, Sai H A (SH); Anderson, Anjenique (A); Von Lindern, Jana J (JJ); Beasley, David W C (DW); Barrett, Alan D T (AD); Gorenstein, David G (DG);

Affiliation: Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-1157, USA.

Grants: U01 AI054827 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Journal: Virology (Virology), published in United States. (Language: eng)

Reference: 2009-Nov; vol 394 (issue 1) : pp 12-8

Dates: Created 2009/10/26; Completed 2009/11/05;

PMID: 19818466, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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