Trials review: cardiovascular outcome with intensive glycemic control and implications for patients with type 2 diabetes.

Full Abstract

Hyperglycemia is associated with microvascular and macrovascular complications. Intensive glucose control has been shown to reduce microvascular complications. Nevertheless, cardiovascular disease remains the leading cause of death in patients with type 2 diabetes. A positive association exists between hemoglobin A1c level and cardiovascular events, but whether reducing blood glucose will reduce cardiovascular events is still not quite clear. The benefits of intensive glucose control also remain uncertain for the heterogenous group of older patients with type 2 diabetes. This article reviews results of earlier and recently published intervention trials of intensive glucose control and their outcomes and discusses relevant recommendations for adults with type 2 diabetes.

Author information

Author/s: Brown, Siobhan H M (SH); Abdelhafiz, Ahmed H (AH);

Affiliation: Rotherham General Hospital, Rotherham, UK.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Postgraduate medicine (Postgrad Med), published in United States. (Language: eng)

Reference: 2009-Sep; vol 121 (issue 5) : pp 31-41

Dates: Created 2009/10/12; Completed 2009/11/04;

PMID: 19820272, status: MEDLINE (last retrieval date: 11/4/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Aged
Blood Glucose - metabolism
Cardiovascular Diseases - epidemiology; prevention & control
Causality
Comorbidity
Diabetes Complications - epidemiology; prevention & control
Diabetes Mellitus, Type 2 - drug therapy; epidemiology; metabolism
Female
Follow-Up Studies
Great Britain - epidemiology

Great Britain - epidemiology
Hemoglobin A, Glycosylated - metabolism
Humans
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
Male
Middle Aged
Prevalence
Tolbutamide - therapeutic use
Vascular Diseases - epidemiology; prevention & control
Young Adult

Associated Chemicals: Blood Glucose (0) ; Hemoglobin A, Glycosylated (0) ; Hypoglycemic Agents (0) ; hemoglobin A1c protein, human (0) ; Insulin (11061-68-0) ; Tolbutamide (64-77-7)

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