Leukocytoclastic vasculitis associated with insulin aspart in a patient with type 2 diabetes.

Full Abstract

OBJECTIVE: To report a case of leukocytoclastic vasculitis associated with insulin aspart therapy. CASE SUMMARY: A 56-year-old man was admitted to the Department of Endocrinology because of a poorly controlled Type 2 diabetes. In an attempt to reach a tight blood glucose control, an intensive diabetes management consisting of one evening dose of intermediate-acting NPH insulin and three preprandial doses of short-acting insulin aspart was introduced. Two weeks following insulin aspart introduction the patient developed palpable purpura on distal parts of the upper and lower limbs. Four days after the onset of purpura, a skin biopsy was preformed. Histological examination showed vasculitis with perivascular infiltrates of lymphocytes and erythrocyte extravasation. Direct immunofluorescence was negative. On the day the purpuric eruptions appeared, insulin aspart was substituted with regular human insulin. All skin lesions disappeared spontaneously within 8 days. Insulin aspart was not re-administered. DISCUSSION: Other possible causes of vasculitis in this case were excluded by diagnostic tests. The temporal relationship between the insulin aspart administration and the occurrence of purpura, with no further episodes of skin eruptions after discontinuation of the drug, support the hypothesis of an insulin aspart caused vasculitis. Based on the Naranjo's algorithm, the adverse drug reaction could be considered possible. CONCLUSION: Clinicians should be aware of the possibility of leukocytoclastic vasculitis occurring during insulin aspart treatment.

Author information

Author/s: Marusic, S (S); Vlahovic-Palcevski, V (V); Ljubanovic, D (D);

Affiliation: Department of Clinical Pharmacology, University Hospital Dubrava, Zagreb, Croatia. srmarusic(-atsign-)inet.hr

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: International journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther), published in Germany. (Language: eng)

Reference: 2009-Oct; vol 47 (issue 10) : pp 603-5

Dates: Created 2009/10/14; Completed 2009/11/05;

PMID: 19825323, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.