Corticostriatal Interactions during Learning, Memory Processing, and Decision Making.

Full Abstract

This mini-symposium aims to integrate recent insights from anatomy, behavior, and neurophysiology, highlighting the anatomical organization, behavioral significance, and information-processing mechanisms of corticostriatal interactions. In this summary of topics, which is not meant to provide a comprehensive survey, we will first review the anatomy of corticostriatal circuits, comparing different ways by which "loops" of cortical-basal ganglia circuits communicate. Next, we will address the causal importance and systems-neurophysiological mechanisms of corticostriatal interactions for memory, emphasizing the communication between hippocampus and ventral striatum during contextual conditioning. Furthermore, ensemble recording techniques have been applied to compare information processing in the dorsal and ventral striatum to predictions from reinforcement learning theory. We will next discuss how neural activity develops in corticostriatal areas when habits are learned. Finally, we will evaluate the role of GABAergic interneurons in dynamically transforming cortical inputs into striatal output during learning and decision making.

Author information

Author/s: Pennartz, Cyriel M A (CM); Berke, Joshua D (JD); Graybiel, Ann M (AM); Ito, Rutsuko (R); Lansink, Carien S (CS); van der Meer, Matthijs (M); Redish, A David (AD); Smith, Kyle S (KS); Voorn, Pieter (P);

Affiliation: University of Amsterdam, Swammerdam Institute for Life Sciences Center for Neuroscience, 1098 XH Amsterdam, The Netherlands. c.m.a.pennartz(-atsign-)uva.nl

Grants: DA14318 (Agency:NIDA NIH HHS) ; F32-MH085454 (Agency:NIMH NIH HHS) ; MH12908 (Agency:NIMH NIH HHS) ; MH60379 (Agency:NIMH NIH HHS) ; R01 MH80318 (Agency:NIMH NIH HHS) ; W078197 (Agency:Wellcome Trust)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2009-Oct; vol 29 (issue 41) : pp 12831-8

Dates: Created 2009/10/15; Completed 2009/10/30;

PMID: 19828796, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )

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