Research article summary (published 12 Oct 2009):

Cortical representation of ipsilateral arm movements in monkey and man.

Full Abstract

A fundamental organizational principle of the primate motor system is cortical control of contralateral limb movements. Motor areas also appear to play a role in the control of ipsilateral limb movements. Several studies in monkeys have shown that individual neurons in primary motor cortex (M1) may represent, on average, the direction of movements of the ipsilateral arm. Given the increasing body of evidence demonstrating that neural ensembles can reliably represent information with a high temporal resolution, here we characterize the distributed neural representation of ipsilateral upper limb kinematics in both monkey and man. In two macaque monkeys trained to perform center-out reaching movements, we found that the ensemble spiking activity in M1 could continuously represent ipsilateral limb position. Interestingly, this representation was more correlated with joint angles than hand position. Using bilateral electromyography recordings, we excluded the possibility that postural or mirror movements could exclusively account for these findings. In addition, linear methods could decode limb position from cortical field potentials in both monkeys. We also found that M1 spiking activity could control a biomimetic brain-machine interface reflecting ipsilateral kinematics. Finally, we recorded cortical field potentials from three human subjects and also consistently found evidence of a neural representation for ipsilateral movement parameters. Together, our results demonstrate the presence of a high-fidelity neural representation for ipsilateral movement and illustrates that it can be successfully incorporated into a brain-machine interface.

Author information

Author/s: Ganguly, Karunesh (K); Secundo, Lavi (L); Ranade, Gireeja (G); Orsborn, Amy (A); Chang, Edward F (EF); Dimitrov, Dragan F (DF); Wallis, Jonathan D (JD); Barbaro, Nicholas M (NM); Knight, Robert T (RT); Carmena, Jose M (JM);

Affiliation: Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, California 94720, USA.

Grants: NS21135 (Agency:NINDS NIH HHS) ; P01NS040813 (Agency:NINDS NIH HHS) ; R01DA19028 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2009-Oct; vol 29 (issue 41) : pp 12948-56

Dates: Created 2009/10/15; Completed 2009/10/30;

PMID: 19828809, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Action Potentials - physiology Adolescent Adult Analysis of Variance Animals Arm Brain Mapping Electroencephalography - methods Electromyography - methods Evoked Potentials, Motor - physiology Functional Laterality - physiology

Functional Laterality - physiology Humans Macaca mulatta Male Models, Neurological Motor Cortex - physiology Movement - physiology Predictive Value of Tests Task Performance and Analysis User-Computer Interface Young Adult

Related articles

These are the highest related articles currently in the database:

• Metabolic activity pattern in the motor and somatosensory cortex of monkeys performing a visually guided reaching task with one forelimb. 29 Apr 1996
• Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil transcranial magnetic stimulation during reach planning toward contralateral space. 2 Jun 2008
• Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke. 4 Mar 2008

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.