Influence of genetic background on fluoride metabolism in mice.

Full Abstract

A/J and 129P3/J mouse strains have different susceptibilities to dental fluorosis, due to their genetic backgrounds. This study tested whether these differences are due to variations in water intake and/or F metabolism. A/J (susceptible to dental fluorosis) and 129P3/J mice (resistant) received drinking water containing 0, 10, or 50 ppm F. Weekly F intake, excretion and retention, and terminal plasma and femur F levels were determined. Dental fluorosis was evaluated clinically and by quantitative fluorescence (QF). Data were tested by two-way ANOVA. Although F intakes by the strains were similar, excretion by A/J mice was significantly higher due to greater urinary F excretion, which resulted in lower plasma and femur F levels. Compared with 129P3/J mice given 50 ppm F, significantly higher QF scores were recorded for A/J mice. In conclusion, these strains differ with respect to several features of F metabolism, and amelogenesis in the 129P3/J strain seems to be unaffected by high F exposure.

Author information

Author/s: Carvalho, J G (JG); Leite, A L (AL); Yan, D (D); Everett, E T (ET); Whitford, G M (GM); Buzalaf, M A R (MA);

Affiliation: Department of Biological Sciences, Bauru Dental School, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru-SP 17012-901, São Paulo, Brazil. mbuzalaf(-atsign-)fob.usp.br

Grants: DE-014853 (Agency:NIDCR NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Journal of dental research (J Dent Res), published in United States. (Language: eng)

Reference: 2009-Nov; vol 88 (issue 11) : pp 1054-8

Dates: Created 2009/10/15; Completed 2009/10/29;

PMID: 19828896, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

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